Naslov
Excretion and long-term retention of cytotoxic drugs

Autori
Javor, Eugen ; Govorčinović, Tihana ; Kranjec Šakić, Martina ; Skelin, Marko ; Pavlica, Vesna ; Šeparović, Robert ; Arbanas, Dahna ; Koroman, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Proceedings Book / Delahunty, Maysson ; Perks, Bea - : Pharma Publishing and Media Europe, 2016, 31-31

Skup
3rd ECOP (European Conference of Oncology Pharmacy)

Mjesto i datum
Dubrovnik, Hrvatska, 19.05.2016. - 21.05.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
excretion, long term retention, cytotoxic drugs

Sažetak
There is a vast number of scientific literature that describe that cytotoxic drug molecules retain on external packaging of the drugs, and on the surfaces inside and outside of the cytotoxic drugs preparation units. What about the excretion of cytotoxic drugs and their long term retention in an organism? Searching through scientific and professional literature that describes elimination and retention of cytotoxic drugs in an organism we come across very useful information. It is proven that platinum compounds retain in the body for a long time. Cisplatin highly concentrates in the liver, kidneys and prostate, while something less in bladder, testicles, muscles, pancreas and spleen. In patients who received the last dose of cisplatin 8 years ago, there has been noted 500 times higher concentrations of platinum than those allowed in urine and serum. [1] Gietema and associates state that cisplatin can be detected in plasma even 20 years after the last cisplatin chemotherapy application. [2] During the period of time from 8 to 23 months after the last oxaliplatin dose application, patients had 30 times higher plasma concentrations of platinum than the control group. [3] Seven patients had ratio of cyclophosphamide concentrations in plasma and saliva of 0.77 +/- 0.24 after intravenous and oral application. [4] Doxorubicin excretes in saliva 2-4 hours after intravenous application, but high concentrations of doxorubicin (in few patients almost equivalent to the one in plasma) have been found in saliva 48 hours after application of the drug. [5] It is important to mention that this data was taken from a study that lasted only 48 hours and it can’t be certainly concluded that there are no high concentrations of doxorubicin in saliva even after 48 hours. Liposomal doxorubicin excretes via sweat glands. It was noted that 3 hours after intravenous application there was excretion of liposomal doxorubicin on the skin surface. In this case stratum corneum serves as a container of doxorubicin which results with higher dermatologic toxicity. [6] So far there is no enough information about how long cytotoxic drugs retain in the body fluids, and we can’t make a precise conclusion on how to advise patients regarding handling these drugs in an outpatient setting. According to everything mentioned above, we can conclude that cytotoxic medicines excrete via body fluids, and it is an obligation of oncology pharmacist to warn and counsel patients and their family members about handling these drugs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA