Naslov
Toxicity determination of chemotherapeutic agents in the water by Vibrio fischeri bacteria

Autori
Ašperger, Danijela ; Papac, Josipa ; Čizmić, Mirta ; Perović, Klara ; Halužan, Maja ; Vuković Domanovac, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem - Knjiga sažetaka / Đaković, Marijana ; Miljanić, Snežana ; Šantić, Ana ; Vianello, Robert - Zagreb : Hrvatsko kemijsko društvo, 2017, 227-227

ISBN
978-953-55232-7-7

Skup
25. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Poreč, Hrvatska, 19.04.2017. - 22.04.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
toxicity ; chemotherapeutic agents

Sažetak
The growth of human consumption from year to year increases the use of pharmaceuticals in everyday life. This has extremely negative effect on environment, especially the water, causing the pollution. The problem occurs in the treatment of waste waters because such waters, contaminated with pharmaceuticals, are very difficult to process with conventional methods of treatment. All these facts and the lack of legal regulations that define the maximum permissible concentrations of pharmaceuticals in the environment, encouraged scientists and numerous experts on research and development of modern technologies for wastewater treatment. The aim of this study was to determine toxicity of pure active chemotherapeutic agents of antiparasitics (albendazole, febantel, praziquantel), antibiotics (cefdinir, nitrofurantoin), a bisphosphonate for treating and preventing osteoporosis (alendronate), a rheumatoid (hydroxychloroquine), an antiemetic (metoclopramide), and a NMDA receptor antagonists (memantine). It si important to determine the toxicity of pure active components because it helps determining their toxicity in the environment and also helps to track the toxicity of their metabolites and degradation products. To determine the toxicity, bioluminescent method DIN 38412 –L-34 was applied where test organisms used were Vibrio fischeri bacteria. They are sensitive to organic contaminants whose presence causes an inhibition of bacteria luminescence. Measurements have shown that all pharmaceuticals with higher concentrations cause inhibition of bacterial culture. Which concentration will be taken as the limit one, depends on the severity of the observed effect. For the most pharmaceuticals the action after their usage is not known therefore it is necessary to implement more and more of this kind of measurements, especially for antibiotics and estrogens, which are suspected to persist in environment, either due to disability of biodegradation or due to continuous discharge.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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