Naslov
Meso- and racemic-DMSA as antidotes in heavy metal poisoning

Autori
Blanuša, Maja ; Piasek, Martina ; Kostial, Krista ; Jones, Mark M. ; Singh, Pramod K.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Technical Program CBMTS - Industry II / Croatian Organizing Comittee, ASA - Zagreb, 2001, 23-23

Skup
World congress on chemical and biological terrorism

Mjesto i datum
Dubrovnik, Hrvatska, 22.04.2001. - 27.04.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lead; cadmium; mercury; meso- and racemic-1; 3-dimercaptosuccinic acid
(lead; cadmium; mercury; meso- adn racemic-1; 3-dimercaptosuccinic acid)

Sažetak
Lead, cadmium and mercury, well known toxic metals, could be used in a chemical terrorist attack. Chelating agents are the only antidotes which promote toxic metals elimination from the body. At present meso-1, 3-dimercaptosuccinic acid (meso-DMSA) is the optimal officially accepted antidote in poisoning with lead and mercury that can be used orally. However, a racemic form of meso-DMSA (rac-DMSA) seems to have higher stability constants with toxic metals but was not yet thoroughly studied in vivo. In an experimental model using female Wistar rats, the efficiency of two DMSA isomers was tested after lead, mercury and cadmium poisoning. Each metal was administered in a single intraperitoneal injection of 0, 5 to 2, 0 mmol/kg in the form of lead acetate (stable lead) during 5 days, mercury chloride with 203Hg (radioactive tracer) during 5 days or cadmium chloride with radioactive 109Cd. The therapy was started either immediately or 3 to 5 days after poisoning with heavy metals and lasted 4 days. Stable lead was measured by atomic absorption spectrometry and radioactive isotopes by scintillation gamma counter. At the end of each experiment, animals were killed and metals were measured in organs (liver, kidneys, brain) and in the femur. Results of our experiments show that rac-DMSA is more efficient in reducing body burden of metals and target organ retention than meso-DMSA. These studies are in progress with the aim to find out weather rac-DMSA could be applied clinically.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA