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Pregled bibliografske jedinice broj: 873179

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Fan, Qiao; Verhoeven, Virginie J. M.; Wojciechowski, Robert; ...; Polašek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; ...; Mizuki, Nobuhisa et al.
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error // Nature communications, 7 (2017), 11008, 12 doi:10.1038/ncomms11008 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 873179 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Autori
Fan, Qiao ; Verhoeven, Virginie J. M. ; Wojciechowski, Robert ; ... ; Polašek, Ozren ; Campbell, Harry ; Rudan, Igor ; Vatavuk, Zoran ; ... ; Mizuki, Nobuhisa ; Meguro, Akira ; Makela, Kari Matti

Izvornik
Nature communications (2041-1723) 7 (2017); 11008, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
refractive error ; gene

Sažetak
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40, 036 adults from 25 studies of European ancestry and 10, 315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
MZOS-216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Ying Fan (autor)

Avatar Url Zoran Vatavuk (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Fan, Qiao; Verhoeven, Virginie J. M.; Wojciechowski, Robert; ...; Polašek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; ...; Mizuki, Nobuhisa et al.
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error // Nature communications, 7 (2017), 11008, 12 doi:10.1038/ncomms11008 (međunarodna recenzija, članak, znanstveni)
Fan, Q., Verhoeven, V., Wojciechowski, R., ..., Polašek, O., Campbell, H., Rudan, I., Vatavuk, Z., ... & Mizuki, N. (2017) Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nature communications, 7, 11008, 12 doi:10.1038/ncomms11008.
@article{article, author = {Fan, Qiao and Verhoeven, Virginie J. M. and Wojciechowski, Robert and Pola\v{s}ek, Ozren and Campbell, Harry and Rudan, Igor and Vatavuk, Zoran and Mizuki, Nobuhisa and Meguro, Akira and Makela, Kari Matti}, year = {2017}, pages = {12}, DOI = {10.1038/ncomms11008}, chapter = {11008}, keywords = {refractive error, gene}, journal = {Nature communications}, doi = {10.1038/ncomms11008}, volume = {7}, issn = {2041-1723}, title = {Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error}, keyword = {refractive error, gene}, chapternumber = {11008} }
@article{article, author = {Fan, Qiao and Verhoeven, Virginie J. M. and Wojciechowski, Robert and Pola\v{s}ek, Ozren and Campbell, Harry and Rudan, Igor and Vatavuk, Zoran and Mizuki, Nobuhisa and Meguro, Akira and Makela, Kari Matti}, year = {2017}, pages = {12}, DOI = {10.1038/ncomms11008}, chapter = {11008}, keywords = {refractive error, gene}, journal = {Nature communications}, doi = {10.1038/ncomms11008}, volume = {7}, issn = {2041-1723}, title = {Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error}, keyword = {refractive error, gene}, chapternumber = {11008} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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