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Pregled bibliografske jedinice broj: 873146

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Aschard, H.; ...; Polašek, Ozren; ...; Kraft, P.
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function // International journal of epidemiology, 46 (2017), 3; 894-904 doi:10.1093/ije/dyw318 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 873146 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Autori
Aschard, H. ; ... ; Polašek, Ozren ; ... ; Kraft, P.

Izvornik
International journal of epidemiology (0300-5771) 46 (2017), 3; 894-904

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genome ; FEV1/FVC ; smoking ; gene–environment interaction ; genetic risk score

Sažetak
Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV1 (forced expiratory volume in 1 second) or FEV1/FVC (FEV1/forced vital capacity). Although the main effects of smoking and genetic loci are well established, the question of potential gene-by-smoking interaction effect remains unanswered. The aim of the present study was to assess, using a genetic risk score approach, whether the effect of these 26 loci on pulmonary function is influenced by smoking. We evaluated the interaction between smoking exposure, considered as either ever vs never or pack-years, and a 26-single nucleotide polymorphisms (SNPs) genetic risk score in relation to FEV1 or FEV1/FVC in 50 047 participants of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and SpiroMeta consortia. We identified an interaction (βint = -0.036, 95% confidence interval, -0.040 to -0.032, P = 0.00057) between an unweighted 26 SNP genetic risk score and smoking status (ever/never) on the FEV1/FVC ratio. In interpreting this interaction, we showed that the genetic risk of falling below the FEV 1: /FVC threshold used to diagnose chronic obstructive pulmonary disease is higher among ever smokers than among never smokers. A replication analysis in two independent datasets, although not statistically significant, showed a similar trend in the interaction effect. This study highlights the benefit of using genetic risk scores for identifying interactions missed when studying individual SNPs and shows, for the first time, that persons with the highest genetic risk for low FEV1/FVC may be more susceptible to the deleterious effects of smoking.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
MZOS-216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi academic.oup.com

Citiraj ovu publikaciju:

Aschard, H.; ...; Polašek, Ozren; ...; Kraft, P.
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function // International journal of epidemiology, 46 (2017), 3; 894-904 doi:10.1093/ije/dyw318 (međunarodna recenzija, članak, znanstveni)
Aschard, H., ..., Polašek, O., ... & Kraft, P. (2017) Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. International journal of epidemiology, 46 (3), 894-904 doi:10.1093/ije/dyw318.
@article{article, author = {Aschard, H. and Pola\v{s}ek, Ozren and Kraft, P.}, year = {2017}, pages = {894-904}, DOI = {10.1093/ije/dyw318}, keywords = {genome, FEV1/FVC, smoking, gene–environment interaction, genetic risk score}, journal = {International journal of epidemiology}, doi = {10.1093/ije/dyw318}, volume = {46}, number = {3}, issn = {0300-5771}, title = {Evidence for large-scale gene-by-smoking interaction effects on pulmonary function}, keyword = {genome, FEV1/FVC, smoking, gene–environment interaction, genetic risk score} }
@article{article, author = {Aschard, H. and Pola\v{s}ek, Ozren and Kraft, P.}, year = {2017}, pages = {894-904}, DOI = {10.1093/ije/dyw318}, keywords = {genome, FEV1/FVC, smoking, gene–environment interaction, genetic risk score}, journal = {International journal of epidemiology}, doi = {10.1093/ije/dyw318}, volume = {46}, number = {3}, issn = {0300-5771}, title = {Evidence for large-scale gene-by-smoking interaction effects on pulmonary function}, keyword = {genome, FEV1/FVC, smoking, gene–environment interaction, genetic risk score} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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