Naslov
Minimal artificial enzymes: Application of "backdoor induction" in asymmetric catalysis

Autori
Kirin, Srećko I.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog : knjiga sažetaka = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog” : Book of Abstracts / Šantić, Ana ; Đaković, Marijana - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2017, 35-35

ISBN
978-953-552327-7

Skup
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog”

Mjesto i datum
Poreč, Hrvatska, 19.04.2017. - 22.04.2017

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
artificial metalloenzymes

Sažetak
The development of new small-molecule transition metal catalysts for asymmetric reactions is often fuelled by imitating metalloenzyme active sites. Nevertheless, small-molecule transition metal catalysts are still easily outperformed by metalloenzymes in terms of both selectivity and reaction rates. It is obvious that mimicking the active site alone is not sufficient to replicate metalloenzyme activity. Therefore we design artificial metalloenzymes that contain not only an enzyme active site mimic but also a minimal functional outercoordination sphere. A major feature of these minimal artificial enzymes is "backdoor induction" of chirality via hydrogen bonding and other non-covalent interactions between distant chiral amide substituents, e. g. amino acids, diamines or dicarboxylic acids. Additional favorable properties are cheap synthesis by standard chemical methods as well as possible application to a broad range of substrates. In this presentation, several selected approaches for the development of new catalytic systems will be discussed [1]. Particular emphasis will be focused on supramolecular systems comprising well defined artificial secondary structures [2], with the potential to transmit chiral information from the outer-coordination sphere to the prochiral catalytically active metal centre.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA