Naslov
Multiclass determination of new psychoactive substances in municipal wastewater

Autori
Senta, Ivan ; Krizman, Ivona ; Ahel, Marijan ; Terzic, Senka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pittcon Conference and Exposition : Abstracts / - , 2016

Skup
Pittcon Conference

Mjesto i datum
Atlanta (GA), Sjedinjene Američke Države, 06.03.2016. - 10.03.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Drugs ; Environmental, Waste and Sludge ; Liquid Chromatography/Mass Spectroscopy ; Solid Phase Extraction

Sažetak
Beside the "traditional" illicit drugs, such as cocaine, heroin, and marijuana, there is a growing concern about the use of modern "designer drugs" that have emerged in large numbers over the past few years. In this work, a sensitive and selective method for simultaneous determination of 24 synthetic psychoactive compounds, including amphetamine, substituted amphetamines and cathinones, in raw wastewater (RW) and secondary effluent (SE) was developed. Samples were enriched by solid phase extraction (SPE) on mixed-mode reversed- phase/strong cation-exchange sorbent and analysed by reversed-phase liquid chromatography coupled to electrospray ionisation tandem mass spectrometry (LC-MS/MS). The target compounds were separated on a Synergi Hydro column and detected using multiple reaction monitoring (MRM) in positive polarity. Reliable quantification was achieved by using several deuterated analogues as surrogate standards. Careful optimisation and validation of the procedure resulted in a reliable determination of all target analytes in low ng/L range for both RW and SE, which makes the method suitable for the application in sewage epidemiology. The method was applied for assessment of selected compounds in municipal wastewater from Croatia. It was shown that the well-known synthetic illicit drugs, amphetamine and MDMA still dominate in all samples (concentrations up to 545 ng/L and 55 ng/L in RW, respectively), while the new psychoactive substances were detected very rarely in low concentrations.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Kemija

POVEZANOST RADA