Naslov
Impact of diabetes on mortality in peripheral artery disease: a meta-analysis

Autori
Vrsalović, Mislav ; Vučur, Ksenija ; Vrsalović Presečki, Ana ; Fabijanić, Damir ; Milošević, Milan

Izvornik
Clinical cardiology (0160-9289) 40 (2017), 5; 287-291

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
peripheral artery disease ; critical limb ischemia ; diabetes ; mortality ; meta-analysis

Sažetak
Background: There are accumulating studies showing the association between diabetes and all-cause mortality in peripheral vascular disease. However, the results in these studies are con-flicting regarding the impact of diabetes on outcome.Hypothesis: Diabetes is associated with increased risk of mortality in peripheral artery disease.Methods: Using MEDLINE and Scopus, we searched for studies published before January2016. Additionally, studies were identified by manual search of references of original articles orreview studies on this topic. Of the 1072 initially identified records, 21 studies with 15, 857patients were included in the final analysis.Results: Diabetes was associated with a statistically significant increased risk of all-causemortality (odds ratio: 1.89, 95% confidence interval: 1.51- 2.35, P < 0.001), without detectedpublication bias (Egger bias = 0.75, P = 0.631). The stronger effect on outcome was obtainedin patients with critical limb ischemia (odds ratio: 2.38, 95% confidence interval: 1.22-4.63, P < 0.001) as the most severe form of peripheral vascular disease.Conclusions: Diabetes is associated with an increased risk of mortality in peripheral vasculardisease, and the effect is even more pronounced in patients with critical limb ischemia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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