Naslov
Neuroendocrine tumor of cecum in patient treated with imatinib mesylate for blastic phase of chronic myeloid leukemia.

Autori
Novaković, Sabina ; Kovač Peić, Anamarija ; Holik, Hrvoje ; Coha, Božena

Izvornik
Acta clinica belgica (1784-3286) 72 (2017), 6; 461-464

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
tyrosine kinase inhibitor ; secondary malignancy ; ascites ; Myeloproliferative disease

Sažetak
Imatinib mesylate (IM), a tyrosine kinase inhibitor, is the treatment of choice in patients with chronic myeloid leukemia (CML). It is considered a very safe drug, with mostly mild and reversible side effects. Lately, it has been suggested that adverse events may occur after a long term. We report a case of a 72-year-old woman diagnosed with blastic phase of Philadelphia chromosome positive CML treated with IM for 28 months. The patient presented first with ascites as a side effect of the drug. When the ascites re- occurred, it was caused by neuroendocrine tumor (NET) with peritoneal carcinomatosis. We believe this is the first case of a NET as a secondary malignancy (SM) after IM treatment. SM have been described in patients on IM before. It is unclear whether these tumors are caused by imatinib or found more easily because of close follow-up.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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