Naslov
Cardiovascular effect of lead and manganese - occupational, environmental and experimental studies

Autori
Šarić, Marko ; Piasek, Martina ; Blanuša, Maja

Izvornik
Advances in clinical and experimental medicine (1230-025X) 10 (2001), 2; 165-174

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
arterial; hypertension; hypotension; mechanisms; epidemiological studies
(arterial; hypertension; hypotension; mechanisms; epidemiological)

Sažetak
The review covers the most important literature data on cardiovascular effects of lead summarized in the WHO document on inorganic lead in 1995, as well as selected recent literature data on cardiovascular effects of both lead and manganese up to the year 2000. Clinical, epidemiological, and animal studies in the same field carried out at the Institute of Medical Research and Occupational Health in Zagreb, Croatia are also presented. The results of our studies show the transitory hypertensive effect of lead during acute intoxication with lead colic. There are also indications that long-term exposure to elevated lead levels, starting from childhood or repeated lead poisonings, may induce an increase in blood pressure values usually combined with renal failure. Epidemiological studies show that, in addition to higher lead levels, lower calcium intake contributes to increased blood pressure. Animal studies show that exposure to moderate or high lead doses during pregnancy and lactation causes no effect on blood pressure either in mother rats or in their perinatally exposed offspring. As far as manganese exposure is concerned, our epidemiological observations confirm findings from animal experiments of the hypotensive effects of manganese on systolic blood pressure. Difference in the effects between systolic and diastolic blood pressure could be explained by an action of manganese ions on the myocardium.//

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA