Naslov
Tripeptide hydrogelator (ffa) as a minimalist model of aggregation of a beta proteins

Autori
Frkanec, Leo

Izvornik
Systems Chemistry in Paris, École Normale Supérieure, Paris,

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
2017

Ključne riječi
tripeptides, gels, Aβ-protein, β-sheet, amyloid dyes, biomaterial,

Sažetak
Synthesis, characterization and self-assembly of small peptidic gelators based on amyloid β- protein. Morphology of prepared gels was investigated by Transmission Electron Microscopy (TEM). Organisation in gel assemblies at the molecular and the supramolecular level determined by using spectroscopic methods (NMR, FTIR, CD) pointed towards the β-sheet type of hydrogen bonding self-association of tripeptides in gel aggregates. Binding studies of tripeptide 6 with amyloid dyes, Congo Red and Thioflavin T (ThT) were carried out using fluorescence spectroscopy and confocal microscopy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
Predavanje se održalo 2.-3.2.2017.

POVEZANOST RADA