Naslov
Regional brain perfusion changes in patients with primary generalized epilepsy assessed by Tc-99m-HMPAO and SPECT

Autori
Bajc, Marika ; Basić, Mario ; Hajnšek, Sanja ; Topuzović, Nedeljko

Izvornik
Neurologia croatica (0353-8842) 41 (1991), 1-2; 13-20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tc99m-hexamethylprolenaminoxim (HMPAO) ; single photon emission computerized tomography (SPECT) ; epilepsy ; cerebral perfusion

Sažetak
Cerebral distribution of Tc99m- hexamethylprolenaminoxim (HMPAO) was investigated using single photon emission computerized tomography (SPECT) in 34 patients with primary generalized epilepsy (PGE) during the interictal state. These findings were compared with those in a control group of 9 healthy volunteers. In control subjects uniform selective uptake of HMPAO in cortex, basal ganglia and thalamus was found. In 30 patients (88%) decreased regional perfusion was found as follows: in the cortical region in 6 patients (18%), in the region of the basal ganglia or thalamus in 7 (20%), and in both regions in 17 patients (50%). Four patients had normal SPECT findings. The obtained results permit a hypothesis that the PGE should not be strictly differentiated from the focal epilepsy. A possible explanation of the pathophysiology of PGE has also been discussed.

Izvorni jezik
Engleski

Znanstvena područja
Filozofija, Filologija

POVEZANOST RADA