Naslov
Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour

Autori
Jaehne, Emily ; Klarić, Thomas Stephen ; Koblar, Simon Andrea ; Baune, Bernhard ; Lewis, Martin David

Izvornik
Behavioural brain research (0166-4328) 281 (2015); 276-282

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Anxiety ; Depression ; Memory ; Neuronal PAS domain-containing protein 4 ; Sociability

Sažetak
The transcription factor neuronal PAS domain- containing protein 4 (Npas4), which regulates the formation of inhibitory synapses on excitatory neurons, has been suggested as a candidate gene for neurological and psychiatric conditions such as bipolar depression, autism spectrum and cognitive disorders. A mouse model of Npas4 deficiency has been developed to investigate any role in these disorders. Behavioural characterisation of Npas4(-/-), Npas4(+/-) and Npas4(+/+) mice has been conducted using the open field, elevated zero maze (EZM), Y-maze, sociability test and forced swim test (FST) to investigate a range of behaviours. Npas4(-/-) mice spent more time in the open arm of the EZM than other genotypes, suggesting decreased anxiety-like behaviour. Npas4(+/-) mice, however, were more immobile in the FST than other genotypes, suggesting increased depression-like behaviour, and also showed impaired spatial recognition memory in the Y-maze. There were no differences between genotype in social behaviour. These results suggest that differential levels of Npas4 expression in the brain may regulate anxiety, depression and cognition related disorders.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA