Naslov
Bismuth nanoparticles-carbon nanotubes modified sensor for sulfasalazine analysis

Autori
Nigović, Biljana ; Jurić, Sandra ; Mitrović, Iva

Izvornik
Talanta (0039-9140) 164 (2017); 201-208

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bismuth nanoparticles, Carbon nanotubes, Glassy carbon, Voltammetry, Sulfasalazine

Sažetak
Nanocomposite of bismuth nanoparticles and carbon nanotubes in Nafion matrix was used as modifier for glassy carbon electrode in analysis of anti- inflamatory drug sulfasalazine. The nanocomposite surface exhibited exceptional synergy and remarkable enhancement effect to the voltammetric response of drug. The surface morphology and structure characterization of the modified electrodes was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry. The sensor exhibited excellent electroanalytical performance for drug determination in comparison with bismuth film electrode. The adsorptive stripping square-wave voltammetric signal showed a good linear correlation to sulfasalazine concentration in a broad range from 5.0×10−8 to 1.0×10−5 M with low detection limit of 1.3×10−8 M.The method was successfully utilised for drug quantification in human serum samples and good recoveries were obtained without interference from endogenous substances, 5-aminosalycilic acid and sulfapyridine formed after biotransformation of drug and folic acid co-administered as the supplement during sulfasalazine therapy. Additionally, the proposed sensor was successfully applied to analysis of sulfasalazine content in gastroresistant pharmaceutical dosage forms.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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