Naslov
Environmental photolytic degradation of antibiotic nitrofurantoin

Autori
Biošić, Martina ; Dabić, Dario ; Kocijan, Martina ; Babić, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
16th Ružička days "Today Scienxe – Tomorrow Industry" : Book of abstracts / Jukić, Ante ; Ocelić Bulatović, Vesna - Zagreb, 2016, 22-22

Skup
Ružička days "Today Scienxe – Tomorrow Industry" (16 ; 2016)

Mjesto i datum
Vukovar, Hrvatska, 21.09.2016. - 23.09.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pharmaceuticals, nitrofurantoin, photolysis

Sažetak
Over the past decade, pharmaceuticals have been considered as emerging pollutants due to their continuous input and persistence in the aquatic ecosystems even at low concentrations. Since they could have a great impact on the environment and on human health, public and scientific concern has progressively increased. This area of research has progressively received more attention as many pharmaceuticals in the environment becomes evident. Once pharmaceuticals reach the environment many processes occur reducing their concentration. Generally, both biotic and abiotic processes determined pharmaceuticals fate in the environment. In surface water abiotic transformation occurs via hydrolysis and photodegradation. For pharmaceuticals resistant to hydrolysis, photolysis is predominant pathway of abiotic degradation in surface water. In direct photolysis pharmaceutical molecules absorb solar radiation which causes the break-up of molecules and formation of different photodegradation products with different physicochemical which can be more stable and even more toxic than the parent compounds. Based on the facts that nitrofurantoin is a drug frequently used in human for the treatment of uncomplicated urinary tract infection with relatively high excretion rate (approximately one third excreted unchanged in urine) and the absence of data on its environmental fate, the main objective of the present study was to investigate its photolytic degradation under environmentally relevant conditions. The photolytic degradation was investigated under simulated solar radiation using a Suntest CPS+ simulator equipped with a Xenon lamp and temperature sensor. The device emitted radiation in the wavelength range of 300–800 nm to simulate natural sunlight. To determine photodegradation rate of nitrofurantoin, samples were analyzed by high performance liquid chromatography coupled to diode array detector (HPLC–DAD). The results showed that investigated pharmaceutical degrade quickly and photodegradation followed pseudo first order kinetics with half-life less than 20 minutes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA