Naslov
‘Omics’ biomarkers associated with chronic low back pain: protocol of a retrospective longitudinal study

Autori
Allegri, Massimo ; De Gregori, Manuela ; Minella, Cristina E ; Klersy, Catherine ; Wang, Wei ; Sim, Moira ; Gieger, Christian ; Manz, Judith ; Pemberton, Iain K ; MacDougall, Jane ; Williams, Frances MK ; Van Zundert, Jan ; Buyse, Klaas ; Lauc, Gordan ; Gudelj, Ivan ; Primorac, Dragan ; Skelin, Andrea ; Aulchenko, Yurii S ; Lennart, C. Karssen ; Kapural, Leonardo ; Rauck, Richard ; Fanelli, Guido

Izvornik
BMJ Open (2044-6055) 6 (2016), 10; E012070-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, protocol, znanstveni

Ključne riječi
chronic low back pain (LBP), Omics biomarkers, retrospective study

Sažetak
Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molecular pathologies and interaction with psychosocial factors that leads to a range of clinical manifestations. There is still much to understand in the underlying pathological processes and the non-psychosocial factors which account for differences in outcomes. Biomarkers that may be objectively used for diagnosis and personalised, targeted and cost- effective treatment are still lacking. Therefore, any data that may be obtained at the ‘-omics’ level (glycomics, Activomics and genome-wide association studies—GWAS) may be helpful to use as dynamic biomarkers for elucidating CLBP pathogenesis and may ultimately provide prognostic information too. By means of a retrospective, observational, case-cohort, multicentre study, we aim to investigate new promising biomarkers potentially able to solve some of the issues related to CLBP

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA