Naslov
Mono- and bis-dipicolinic acid heterocyclic derivatives – thiosemicarbazides, triazoles, oxadiazoles and thiazolidinones as antifungal and antioxidant agents

Autori
Molnar, Maja ; Pavić, Valentina ; Šarkanj, Bojan ; Čačić, Milan ; Vuković, Dubravka ; Klenkar, Jelena

Izvornik
Heterocyclic communications (0793-0283) 23 (2017), 1; 35-42

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antifungal ; antioxidant activity ; dipicolinic acid ; oxadiazole ; thiadiazole ; thiazolidinone ; triazole

Sažetak
A series of dipicolinic acid derivatives was synthesized and investigated for antimicrobial and antioxidant activity. Mono and bis derivatives of ethyl dipicolinate were utilized as starting materials for synthesis of mono- and bis-hydrazides. Thiosemicarbazides were obtained by reaction of hydrazides with isothiocyanates and cyclized into triazoles, thiadiazoles, oxadiazoles and thiazolidinones. Some of these products, especially those incorporating a thiazolidinone moiety in their structure, are excellent antioxidants, DPPH scavengers and antifungal agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija

POVEZANOST RADA