Pregled bibliografske jedinice broj: 856443
Changes in gene structure and protein expression of DVL1, DVL2, DVL3 and transcription factors TCF1 and LEF1 in glioblastoma
Changes in gene structure and protein expression of DVL1, DVL2, DVL3 and transcription factors TCF1 and LEF1 in glioblastoma // PhD Day 2015 Abstract Book
Zagreb, Hrvatska, 2015. str. 27-27 (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 856443 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Changes in gene structure and protein expression of DVL1, DVL2, DVL3 and transcription factors TCF1 and LEF1 in glioblastoma
Autori
Kafka, Anja ; Pećina-Šlaus, Nives
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
PhD Day 2015 Abstract Book
/ - , 2015, 27-27
Skup
Dan doktorata 2015/PhD Day 2015
Mjesto i datum
Zagreb, Hrvatska, 22.05.2015
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
Wnt signaling pathway ; glioblastoma ; Dishevelled (DVL), TCF1, LEF1
Sažetak
Glioblastoma are the most common and the most aggressive tumors of central nervous system and are classified as grade IV astrocytoma by the criteria of the WHO. Wnt signalling pathway is basic cellular pathway whose misregulation plays important roles in tumorigenesis. Dishevelled (DVL) is cytoplasmatic phosphoprotein, who comes first in downstream cascade from Frizzled (Fz) receptor. When the signalization mediated by DVL is disrupted, it consequently induce transcription of target genes regulated by transcription factor TCF1 and LEF1 which results in tumor development and progression. In the present study changes of three homolog genes of Dishevelled (DVL1, DVL2 and DVL3) and their protein expression were investigated in glioblastoma
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb
