Naslov
Comparative Analysis of Azithromycin and Clarithromycin Efficacy and Tolerability in the Treatment of Chronic Prostatitis Caused by Chlamydia trachomatis

Autori
Škerk, Višnja ; Schönwald, Slavko ; Krhen, Ivan ; Markovinović, Leo ; Baršić, Bruno ; Mareković, Ivana ; Roglić, Srđan ; Zeljko, Zvonimir ; Vince, Adriana ; Čajić, Vjeran

Izvornik
Journal of Chemotherapy (1120-009X) 14 (2002), 4; 384-389

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
azithromycin; clarithromycin; prostatitis; Chlamydia trachomatis

Sažetak
A total of 123 patients, older than 18 years of age, with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage, were examined. The patients were randomized to receive a total of 4.5 g of azithromycin for 3 weeks, given as a 3-day therapy of 1x500 mg weekly or clarithromycin 500 mg b.i.d. for 15 days. Patients' sexual partners were treated at the same time. Clinical and bacteriological efficacy were evaluated 4-6 weeks after the end of therapy. In the group of patients with chronic chlamydial prostatitis the eradication rates (azithromycin 37/46, clarithromycin 36/45) and the clinical cure rates (azithromycin 32/46, clarithromycin 32/45) were not significantly different with regards to the administered drug (p 0.05). In the group of patients with asymptomatic chlamydial prostatitis the eradication rates (azithromycin 11/16, clarithromycin 10/15) were not significantly different with regards to the administered drug (p=1.00, OR=1.1).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA