Naslov
Expression patterns of Wnt signaling key components: Dishevelleds, transcription factors TCF/LEF and antagonist SFRP3 in astrocytic brain tumors

Autori
Kafka, Anja ; Varošanec, Ana Maria ; Marković, Leon ; Krsnik, Željka ; Tomas, Davor ; Bačić, Mateja ; Pećina-Šlaus, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
5th Croatian Neuroscience Congress / - , 2015

Skup
5th Croatian Neuroscience Congress

Mjesto i datum
Split, Hrvatska, 17.09.2015. - 19.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Wnt signaling ; Dishevelleds ; transcription factors TCF/LEF ; SFRP3 ; astrocytic brain tumors

Sažetak
Recently it has become evident that human astrocytic tumors’ growth is driven by complex signaling networks. Wnt signaling is a crucial factor in the development of many cancers and we believe that aberrant Wnt signaling has an important role in the development of astrocytic brain tumors, too. Since molecular and genetic landscapes of human astrocytic brain tumors still need elucidation we decided to study key players of Wnt signaling, dishevelleds (DVL1, DVL2, DVL3), TCF1 and LEF1 transcription factors, and SFRP3, an antagonist of Wnt signaling, in the set of human astrocytic brain tumors. Genetic changes were analyzed by polymerase chain reaction/loss of heterozygosity (LOH) and protein expressions by immunohistochemistry.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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