Naslov
Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation

Autori
Stojković, Ranko ; Fučić, Aleksandra ; Ivanković, Dušica ; Jukić, Zoran ; Radulović, Petra ; Grah, Josip ; Kovačević, Nenad ; Barišić, Lovro ; Krušlin, Božo

Izvornik
Arhiv za higijenu rada i toksikologiju – Archives of Industrial Hygiene and Toxicology (0004-1254) 67 (2016), 4; 297-303

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gamma radiation ; micronucleus ; oestrogen ; radiosensitivity ; testosterone

Sažetak
The mechanisms that lead to sex and age differences in biological responses to exposure to ionising radiation and related health risks have still not been investigated to a satisfactory extent. The significance of sex hormones in the aetiology of radiogenic cancer types requires a better understanding of the mechanisms involved, especially during organism development. The aim of this study was to show age and sex differences in genome damage between prepubertal and adult mice after single exposure to gamma radiation. Genome damage was measured 24 h, 48 h, and 72 h after exposure of 3-week and 12-week old BALB/CJ mice to 8 Gy of gamma radiation using an in vivo micronucleus assay. There was a significantly higher genome damage in prepubertal than in adult animals of both sexes for all sampling times. Irradiation caused a higher frequency of micronuclei in males of both age groups. Our study confirms sex differences in the susceptibility to effects of ionising radiation in mice and is the first to show that such a difference occurs already at prepubertal age.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA