Naslov
Peripheral Blood Plasmacytoid Dendritic Cells at Day 100 Can Predict Outcome after Allogeneic Stem Cell Transplantation

Autori
Perić, Zinaida ; Cahu, Xavier ; Malard, Florent ; Brissot, Eolia ; Chevallier, Patrice ; Guillaume, Thierry ; Gregoire, Marc ; Gaugler, Beatrice ; Mohty, Mohamad

Izvornik
Biology of blood and marrow transplantation (1083-8791) 21 (2015), 8; 1431-1436

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Allogeneic transplantation ; GVHD ; Outcome ; Plasmacytoid dendritic cell

Sažetak
The rapidly increasing use of allogeneic stem cell transplantation (allo-SCT) emphasizes the need for identifying variables predictive of its outcome. Plasmacytoid dendritic cells (pDCs) play a major role in establishing immune competence and in several autoimmune diseases. Thus, we investigated whether pDCs might influence the outcome of patients after allo-SCT in 79 consecutive patients who underwent this procedure. pDCs were identified in the blood of patients at day 100 after allo-SCT by staining peripheral blood mononuclear cells for surface markers and intracellular cytokines and analyzing them on a flow cytometer. We found the pDC level at day 100 was not influenced by patient or graft characteristics, and only the absence of previous grades II to IV acute graft-versus-host disease was significantly associated with higher levels of blood pDCs after allo-SCT (OR, .67 ; 95% CI, .54 to .83 ; P = .0004). Using the median value of pDCs at day 100 to divide the patients into 2 distinct groups, we observed that a low pDC level was correlated with a worse overall survival (55% versus 86%, P = .007). In a multivariate analysis, only low pDC level (OR, 3.41 ; 95% CI, 1.19 to 9.79 ; P = .02) and older patient age (OR, 5.16 ; 95% CI, 1.15 to 23.14 ; P = .03) were significantly predictive of increased risk of death. We conclude that monitoring of pDC may be useful for patient management and may have a significant impact on the probability of a favorable outcome of allo-SCT.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA