Pregled bibliografske jedinice broj: 85164
Micronucleus distribution in human peripheral blood lymphocytes treated in vitro with cadmium chloride in G0 and S phase of the cell cycle
Micronucleus distribution in human peripheral blood lymphocytes treated in vitro with cadmium chloride in G0 and S phase of the cell cycle // Chemosphere, 49 (2002), 91-95 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 85164 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Micronucleus distribution in human peripheral blood lymphocytes treated in vitro with cadmium chloride in G0 and S phase of the cell cycle
Autori
Kašuba, Vilena ; Rozgaj, Ružica
Izvornik
Chemosphere (0045-6535) 49
(2002);
91-95
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
cadmium chloride; micronucleus assay; G0 phase; S phase; cell cycle
Sažetak
Cadmium chloride (CdCl2 x H2O) in concentrations 10 -3 to 10 -6 M was tested for genotoxicity in human lymphocytes in vitro. The DNA damage was expressed through the occurrence of micronuclei (MN) and was detected using the cytochalasin-B-blocked MN assay. Human blood was treated in the G0 and S phse of the cell cycle. All except the highest concentration of cadmium chloride of 10 -3M applied in the G0 phase of the cell cycle resulted in the increase in MN cells, but it was not statistically significant. Cadmium chloride added to the cultures in the concentration of 10 -3M affected the cell growth regardless of the phase. Cadmium chloride added to cultures 24 h after their initiation (early S phase) wasfound to significantly increase the MN frequency in 10 -4 to 10 -6 M concentrations (P>0.05).
Izvorni jezik
Engleski
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
