Naslov
Synthesis, structure and biological study of Gallium(III) complexes as model radiopharmaceuticals

Autori
Esterhuysen, Marisca ; Brink, Alice ; Roodt, Andreas ; Zbačnik, Marija ; Slabbert, Kobus J.P. ; Beukes, Phillip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Physica Medica / - : Elsevier, 2016, P21-P21

Skup
54th National Congress of the South African Association of Physicists in Medicine and Biology (SAAPMB)

Mjesto i datum
Cape Town, Južnoafrička Republika, 06.09.2016. - 09.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
radiopharmaceuticals; Schiff base; gallium(III)

Sažetak
67Ga radiopharmaceuticals have been associated with the diagnosis of lymphomas and inflammation. This isotope has a half-life of approximately three days and can be utilized for quick and effective basic biological testing. Our interest is therefore the design and synthesis of various gallium complexes which would be evaluated in solid and solution state via nuclear magnetic resonance (NMR), infrared spectroscopy (IR) and X-ray diffraction (XRD). The chemical behaviour in solution state is compared to the absolute configuration of the gallium complexes to improve the understanding of any factors which may influence the biological properties of the metallo-organic complexes. An important aspect in pharmaceutical design is the synthesis of complexes to accommodate aspects such as the ease of synthesis ; purity ; environmental influences ; as well as the synthesis conducted by medical personnel and not synthetic chemists. Three novel Schiff base ligands (S1, S2 and S3) were prepared by economical and environmentally friendly methods described above and used for the radiolabelling with 67Ga. These ligands were characterized by NMR, IR and XRD. All three radiolabelled ligands utilized by CHO-K1 cells and showed an increase in cellular uptake when compared to the 67Ga chloride control (67GaCl3). Compared to 67GaCl3, no significant growth delay was observed in the cells regardless of the ligand used for the radiolabeling experiment. An increased amount of radioactivity per cell is required to fully report the conditions needed for effective growth inhibition of cells and the possibility of it being suitable as a potential diagnostic and/or therapeutic pharmaceutical.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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