Naslov
The effects of IL-18 on perforin mediated cytolytic activity of decidual and peripheral blood lymphocytes of first trimester normal human pregnancy

Autori
Sotosek, Vlatka ; Laskarin, Gordana ; Bogovic, Tatjana ; Cupurdija, Kristijan ; Randic, Ljiljana ; Podack, Echard R ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Program and Abstracts in American Journal of Reproductive Immunology, 46:No1:53, 2001. (CC) / - , 2001, 53-53

Skup
VIII International Congress of Reproductive Immunology

Mjesto i datum
Opatija, Hrvatska, 02.07.2001. - 06.07.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
interleukin 18; lymphocytes; perforin; pregnancy

Sažetak
Perforin expressing uterine NK cells are under complex cytokine influence. Interleukin 18 (IL-18) on a dose dependent manner up-regulates perforin expression and cytolytic activity of lymphocytes isolated from the first trimester pregnancy decidua.The addition of IL-12 increased these effects, while IL-15 and IL-10 did not have such effects. These are the first results showing the enhancement of perforin expression and NK cytolytic potential of DL under the influence of IL-18.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA