Naslov
Primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases in a captive brown bear (Ursus arctos) - a case report

Autori
Beck, Ana ; Reljić, Slaven ; Šoštarić-Zuckermann, Ivan-Conrado ; Wrzosek, Marcin ; Huber, Doroteja

Izvornik
Veterinarski arhiv (0372-5480) 86 (2016), 6; 857-865

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
brown bear; ursus arctos; primary renal large B-cell lymphoma; central nervous system metastases; pathology

Sažetak
We present the first report of primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases, in a 7 year-old, captive female brown bear. After 7 months of progressive neurological disease, the animal was euthanized. On necropsy, neoplastic nodules with infiltrative growth in the kidneys were found. Neoplastic proliferation of a similar pattern was found compressing the cerebellum and brain stem, and growing through the nervus maxillaris and nervus ophtalmicus. Histology revealed a highly cellular round cell neoplasm, with an infiltrative diffuse growth pattern through the kidneys and nervous parenchyma. On immunohistochemistry, the neoplastic cells stained for the B-cell marker Pax-5. Our report suggests that lymphoma should be considered as a differential diagnosis in bears with a chronic progressive neurological disease.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Veterinarska medicina

POVEZANOST RADA