Naslov
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Autori
Lu, Yingchang ; Day, Felix R ; ... ; Kolčić, Ivana ; ... ; Polašek, Ozren ; ... ; Smolej Narančić, Nina ; ... ; Rudan, Igor ; ... ; Loos, Ruth J.F.

Izvornik
Nature Communications (2041-1723) 7 (2016); 10495-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
body fat ; cardiometabolic traits ; genome-wide association study ; meta-analysis

Sažetak
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%)in up to 100, 716 individuals. Twelve loci reached genome-wide significance (P<5x10 -8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongy associaed with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA