Naslov
UTJECAJ PROCESNIH PARAMETARA NA GRANULOMETRIJSKA SVOJSTVA MEMANTIN HIDROGEN SULFATA U PROCESU ŠARŽNE KRISTALIZACIJE
(INFLUENCE OF SOLVENT ON GRANULOMETRIC CHARACTERISTIC OF MEMANTINE HYDROGEN SULFATE IN BATCH CRYSTALLIZATION)

Autori
Čavlina, Ana

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Fakultet kemijskog inženjerstav i tehnologije

Mjesto
Zagreb

Datum
23.09

Godina
2015

Stranica
47

Mentor
Prlić Kardum, Jasna

Ključne riječi
šaržna kristalizacija; memantin hidrogen sulfat; granulometrijska svojstva kristala
(batch crystallization; memantine hydrogen sulphate; granulometric properties)

Sažetak
Memantine hydrochloride is pharmaceutically active substance that was found to have role in treatment of Alzheimer's disease. Because needle- shaped crystals of mementine hydrochloride were not appropriate for further use in this particular case it was necessary to find another salt of more suitable formation. After reviewing previous research, memantine hydrogen sulphate was chosen since it has significantly better crystal morphology and hygroscopic behaviour. In this research, through the batch crystallization process, the influence of process parameters and addition of auxiliary components (antisolvent and seed) on granulometric properties of memantine hydrogen sulphate was investigated. Type of solvent and process control influence the saturation of the system, thermodynamics, crystallization kinetics and granulometric properties of crystals. Since the aim of this study was to create a product of appropriate granulometric properties, batch crystallization of memantine hydrogen sulphate by cooling from 2- propranol with addition of antisolvent (ethyl acethate and n- Heptane) and seed within metastable zone was performed. In addition, the filtration test was performed and drying kinetics was determined from data obtained by drying in atmospheric dryer. The shape of crystals was observed with microscopy analysis and the distribution of crystal size was determinated using laser diffraction method. Crystallization kinetics was described using appropriate potential equations.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemijsko inženjerstvo

POVEZANOST RADA