Naslov
Tumor Behaviour: Prognostic Factors in Canine Mast Cell Tumor, Melanoma and Osteosarcoma

Autori
Gudan Kurilj, Andrea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1. međunarodni veterinarski specijalistički simpozij Nove spoznaje u liječenju tumora u malih životinja / - , 2016, 4-4

Skup
1. međunarodni veterinarski specijalistički simpozij Nove spoznaje u liječenju tumora u malih životinja

Mjesto i datum
Zagreb, Hrvatska, 30.06.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
prognostic factors; dog; mast cell tumor; melanoma; osteosarcoma

Sažetak
In recent years, the incidence of various diseases in companion animals has increased along with their extended life expectancy. Among such diseases, the incidence of cancer in dogs seems to be increasing in particular. There is also an increasing need for more accurate diagnostic, prognostic and predictive markers in veterinary oncology because of an increasing number of treatment options, the increased financial costs associated with treatment, and the emotional stress experienced by owners in association with the diease and its treatment. Histopathology remains the gold standard method for cancer diagnosis, but today there are also an exclusive panels of tests that dramatically increase prognostic certainty for different forms of cancers. The highly unreliable and variable nature of histologic grading for canine cutaneous mast cell tumors (MCT) has made it difficult for many veterinary practitioners to offer their clients an accurate prognosis. In order to increase prognostic certainty, a two-tier grading system is proposed as well as cell proliferation analysis, c-Kit PCR to detect internal tandem duplication mutations and KIT immunohistochemistry to analyze expression of this receptor. Accuratelly determining the diagnosis and prognosis of melanocytic tumors is often difficult, especially those of the oral cavity. Recent evidence suggests that a subset of canine oral melanocytic tumors may have a more favorable prognosis than historically thought. A proposed prognostic melanocytic panel includes immunolabeling with Ki67, and assessment of nuclear atypia, mitotic index, and degree of pigmentation for prognostic information. Canine osteosarcoma (OS) presents with heterogenous histologic and clinical features, of which tumor grade, best predicted by blood vessel invasion and mitotic index, and alkaline phosphatase levels seem to be most important for evaluating the prognosis for survival. Several other prognostic and predictive biomarkers (p53, cyclooxygenase-2, epidermal growth factor receptor) for canine OS have been investigated which could be used in prospective patient evaluation. As veterinary oncology continues to advance, there will be an increasing need to identify novel prognostic markers associated with metastasis, recurrence, disease-free interval, and overall survival.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA