Naslov
The pattern of protein phosphorylation in various Streptomyces rimosus oxytetracycline producers’ strains

Autori
Paradžik Tina ; Šarić Ela ; Mikoč Andreja ; Maček Boris ; Herron Paul ; Hunter Ian ; Vujaklija Dušica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
The 2nd International Conference on Post- Translational Modifications in Bacteria

Mjesto i datum
Lyon, Francuska, 18.10.2016. - 21.10.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Streptomyces; Phosphorylation

Sažetak
Streptomyces species are multicellular bacteria that exhibit a complex developmental program and morphological differentiation. The great majority of natural products are synthesized by these bacteria. These natural products include clinically-important antibiotics (tetracyclines, streptomycins, & β-lactams), immunosuppressants and anti-cancer drugs (doxorubicin). The tetracyclines are one of the most successful classes of antibiotics that include oxytetracycline (OTC) produced by S. rimosus. It has been already reported that protein phosphorylation has an important role in the regulation of metabolism and antibiotic production in strepomycetes. Bioinformatic analysis of the S. coelicolor genome predicted 47 eukaryotic-like protein kinases and 49 eukaryotic type protein phosphatases in this species. This number of kinases, although larger than other bacteria is not surprising as the average Streptomyces genome size is almost twice that of E.coli. Based on the phosphoproteome reported for S. coelicolor we predict that the effect of the OTC overproduction in S. rimosus is a consequence of alteration in posttranslational modification (PTM) of regulatory and/or OTC biosynthesis proteins.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA