Pregled bibliografske jedinice broj: 844175
Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. 4. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis
Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. 4. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis // Croatica Chemica Acta, 63 (1990), 4; 565-578 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 844175 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. 4. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis
Autori
Zorc, Branka ; Karlović, Gordana ; Butula, Ivan
Izvornik
Croatica Chemica Acta (0011-1643) 63
(1990), 4;
565-578
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
benzotriazole ; peptide synthesis
Sažetak
The use of the 1-benzotriazolylcarbonyl-(Btc)-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxycarbonyl-(Z)-group. N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respectively. This process is accompanied with separation of benzotriazole and CO2. Advantages and disadvantages of this method of peptide bond formation are discussed.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
