Naslov
Facile synthesis and cytotoxic activity of the first ferrocene-resveratrol conjugate

Autori
Kovač, Veronika ; Kmetič, Ivana ; Murati, Teuta ; Miletić, Marina ; Barišić, Lidija

Izvornik
Croatica chemica acta (0011-1643) 89 (2016), 3; 339-343

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ferrocene ; Ferrocene-resveratrol conjugate ; Hepatoblastoma ; Normal ovary cells ; Resveratrol

Sažetak
The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol (3, 5, 4'-trihydroxystilbene, RSV) moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija

POVEZANOST RADA