Naslov
Blocked K antigen of neonatal red blood cells- which is the critical titre?

Autori
Novoselac, Jurjana ; Raos, Mirela ; Tomac, Gordana ; Lukić, Marija ; Golubić Ćepulić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Special Issue: Abstracts of the 25th Regional Congress of the International Society of Blood Transfusion in conjunction with the 33rd Annual Conference of the British Blood Transfusion Society u Vox Sanguinis 109 (2015) (S1) 1-400 / Devine D - London : Delhi : Wiley-Blackwell, 2015

Skup
25th Regional Congress of the International Society of Blood Transfusion in conjunction with the 33rd Annual Conference of the British Blood Transfusion Society

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 27.06.2015. - 01.07.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
blokirani K antigen; potentno anti-K protutijelo
(blocked K antigen; potent anti-K antibody)

Sažetak
Blocked erythrocyte antigens, first described in 1944, occured due to potent maternal anti-D antibodies that blocked D antigens on foetal red blood cells(RBCs) causing them to be negative when typing with human immunoglobulin M anti-D. The phenomenon is rare and where it does occur antibody doesn't have to be of high titre. There are only two case reports in literature that describe false negative K phenotyping due to blocking with maternal anti- K, phenomenon registered at a titre level of 128 or greater. We want to present a case report of a potent anti-K antibody which blocked K antigens on neonatal RBCs and made them phenotyped as K negative. Complete blocking of K antigen is not widely described, nor perhaps recognized. Manufacturers product inserts should note this possibility and laboratory staff should also have this situation in mind when performing such tests. We proved blocking effect of anti- K at titre of 32, which is lower than previously reported.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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