Naslov
CD44 CORRELATES WITH BIOCHEMICAL RECURRENCE IN PROSTATIC CARCINOMA

Autori
Pajić, Matija ; Belančić, Andrej ; Borovac, Barbara ; Bembić, Massimo ; Đorđević, Gordana ; Mozetič, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd Global Students' Conference of Biomedical Sciences / Faculty of Medicine, University of Belgrade - Beograd, 2016, 45-45

Skup
3rd Global Students' Conference of Biomedical Sciences

Mjesto i datum
Beograd, Srbija, 20.10.2016. - 23.10.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
prostate cancer; CD44 expression; immunohistochemical staining; biochemical recurrence; prognosis

Sažetak
Background: CD44 is the adhesion molecule shown to be an useful marker of aggressiveness of prostate cancer. Aim: The aim of this study was to investigate the expression of CD44 in prostate cancer specimens obtained by prostatectomy, classified according to new Gleason prognostic groups, and to correlate it with biochemical recurrence of the disease. Materials and methods: Tissue microarrays (TMA) of 120 archival, formalin fixed paraffin embedded prostatic carcinoma, were immunohistochemically analysed for CD44 expression. The staining was evaluated as a percentage of membrane and cytoplasmic positive tumor cells multiplied with intensity of staining and was expressed as a histoscore (HSC). Results: Mean CD44 expressed in HSC was 52.1713 ( SD±48.6701) with significant inverse correlation with biochemical recurrence within the 1st Gleason prognostic group (p=0, 049). Statistics with cut off value ≤ 37, 5% showed even better correlation (p=0, 014), so odds for biochemical recurrence is about 3.7 times lower with CD44 tumor expression higher than 37, 5%. On contrary, the correlation of CD44 expression with biochemical recurrence in the other Gleason prognostic groups wasn't found. The possible explanation is that the majority of cases were from 1st Gleason prognostic group (82.64% , n=100), so further collection of prostatic carcinoma from higher Gleason prognostic groups will be needed to conclude if there is also an inverse correlation in the other prognostic groups. Conclusion: Our results showed loss of CD44 expression in tumors with progression of the disease and confirmed the usefulness of this marker in group of tumors which are considered as having excellent prognosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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