Naslov
Pirprofen, indomethacin and placebo in ankylosing spondylitis. Double-blind comparison
(Pirprofen, indomethacin and placebo in ankylosing spondylitis: Double-blind comparison)

Autori
Jajić, Ivo ; Nekora, A. ; Chadri, H.A.

Izvornik
La Nouvelle presse médicale (0301-1518) 11 (1982), 33; 2491-2493

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
[pirprofen ; indomethacin ; placebo ; ankylosing spondylitis]
(pirprofen ; indomethacin ; placebo ; ankylosing spondylitis)

Sažetak
One hundred and four patients with ankylosing spondylitis were involved in a comparative trial carried out in one single centre. They were given either pirprofene (1000 mg/day), indomethacin (125 mg/day) or a placebo for 6 consecutive weeks. Response to treatment was assessed after 1, 2, 4 and 6 weeks on the basis of 4 subjective criteria and 6 standard measurements. The overall therapeutic results were judged by the investigator to be satisfactory in 87% of patients in the pirprofene group, 77% in the indomethacin group and 29% in the placebo group (p less than 0.01). A large number of patients in each group (including 34% on placebo) reported side effects. Treatment was discontinued on account of gastric pain in two patients (one on pirprofen, the other on indomethacin). No abnormalities were detected in laboratory tests.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Izvornik na francuskom jeziku.

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