Naslov
Melatonin-loaded chitosan/PluronicR F127 microspheres as in situ forming hydrogel: an innovative approach toward improved wound healing

Autori
Duvnjak Romić, Marieta ; Šegvić Klarić, Maja ; Lovrić, Jasmina ; Pepić, Ivan ; Cetina-Čižmek, Biserka ; Filipović-Grčić, Jelena, Hafner, Anita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
42nd Annual meeting of Controlled Release Society

Mjesto i datum
Edinburgh, Ujedinjeno Kraljevstvo, 26.06.2015. - 29.06.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
spray-dry; chitosan; Pluronic F127; Factorial design

Sažetak
Melatonin-loaded chitosan-based microspheres as dry powder formulation suitable for wound dressing were developed based on factorial design. Chitosan and chitosan/F127 melatonin- loaded microspheres (MC and MCF, respectively) with very high encapsulation efficiency, small diameter, highly positive surface charge and low moisture content were identified. Microspheres were characterized by good flowability and high rate and extent of fluid uptake. Entrapment of melatonin in chitosan/F127 microspheres potentiated chitosan antimicrobial and antibiofilm activity.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA