Naslov
Cationic nanosystems enhance melatonin ocular delivery: insights form a human corneal epithelial cell line model

Autori
Hafner, Anita ; Lovrić, Jasmina ; Duvnjak Romić, Marieta ; , Juretić, Marina ; Pepić, Ivan ; Cetina-Čižmek, Biserka ; Filipović-Grčić, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
42nd Annual meeting of Controlled Release Society

Mjesto i datum
Edinburgh, Ujedinjeno Kraljevstvo, 26.06.2015. - 29.06.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
HCE-T cells; permeability testing; lecithin/chitosan nanoparticles; Pluronic R F127/chitosan micelles

Sažetak
Two types of nanosystems, namely lecithin/chitosan nanoparticles and Pluronic® F127/chitosan micelles have been prepared and evaluated regarding their potential for ocular delivery of melatonin, known to exert ocular hypotensive effect. The enhancing effect of F127 on melatonin permeation was shown to be hindered in the presence of chitosan. Lecithin/chitosan nanoparticles were characterised by prominent mucoadhesive properties and prolonged melatonin release that was shown to control melatonin permeation across in vitro corneal epithelial model.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA