Naslov
Residues of maduramicin in muscle tisssues of broiler chickens after drug administration

Autori
Bilandžić, Nina ; Solomun Kolanović, Božica ; Varenina, Ivana ; Božić Luburić, Đurđica ; Varga, Ines ; Cvetnić, Luka ; Cvetnić, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016 / Ksenija Durgo - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2016, 39-39

Skup
5th Croatian Congress of Toxicology with International Participation CROTOX 2016

Mjesto i datum
Poreč, Hrvatska, 09.10.2016. - 12.10.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
maduramicin; anticoccidial drugs; broiler chickens; muscle tissues; LC-MS/MS

Sažetak
Maduramicin ammonium, a polyether carboxylic ionophore agent, is authorised for use in feedstuffs as an anticoccidial drug for fattening chickens at a maximum content of 5–6 mg/kg pursuant to Regulation (EU) No 388/2011. The aim of the present study was to investigate maduramicin distribution in the muscle tissues of broilers following treatment with doses exceeding the authorised dose, i.e. a dose about twice the maximum authorised level. Broilers chickens (n=25) were treated with feed medicated with maduramicin in concentrations of 10 mg kg-1 for 21 days. The broilers were killed and muscle tissue was collected over a period of 15 days after the end of administration. Maduramicin concentrations were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionisation. Limit of quantification of the method for maduramicin was 1.29 g kg-1 and recovery 95.8%. The maximum concentrations of maduramicin (44.1 g kg-1) were measured on the first day post-treatment. Concentrations gradually dropped from the third to fifteenth day following drug administration (g kg-1): 3th day 34.0 ; 5th day 15.7 ; 7th day 10.7 ; 9th day 8.44 ; 11th day 6.57 ; 13th day 4.66 ; 15th day 2.37. On the 15th day after the end of treatment, maduramicin levels were still above the limit of quantification. However, maduramicin levels dropped below the permitted maximum residue limits of 30 μg/kg in muscle on the 5th day after the end of treatment. The results indicated rapid excretion of maduramicin from muscle, even when administered at doses exceeding the authorised maximum content.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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