Naslov
Reduction of Ribonucleotide in Prebiotic Conditions

Autori
Barić, Danijela ; Dragičević, Ivan ; Kovačević, Borislav ; Golding, Bernard T. ; Smith, David Matthew

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
MIPoMat Workshop Innovative Surfaces and Materials 2016, Book of Abstracts / - , 2016, 23-23

Skup
MIPoMat Workshop Innovative Surfaces and Materials 2016

Mjesto i datum
Primošten, Hrvatska, 28.08.2016. - 31.08.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ribonucleotides; deoxyribonucleotides; non-enzimatic reduction; DFT; reaction mechanism

Sažetak
The prerequisite for creation of the first living organisms on Earth was the existence of a "molecules of life" such as nucleic acids, amino acids and sugars. Model studies of prebiotic chemistry have revealed persuasive routes for the formation of the building blocks of proteins and RNA, but not DNA. Nowadays, the deoxyribonucleotides required for the construction of DNA are formed in reduction of ribonucleotides catalyzed by radical enzymes ribonucleotide reductases. This work considers potential non-enzymatic routes via intermediate radicals for the ancient formation of deoxynucleotides. We will present several computationally modeled mechanisms of ribonucleotide reduction without the presence of enzymes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA