Naslov
Dietary management and outcome of newly diagnosed pregnant woman with citrullinemia type 1

Autori
Uroić, Valentina ; Mesarić, Nikola ; Pavić, Eva ; Petković Ramadža, Danijela ; Sarnavka, Vladimir ; Fumić, Ksenija ; Zekušić, Marija ; Škaričić, Ana ; Grgić Medić, Marijana ; Zlopaša, Ozrenka ; Gašparović, Vladimir ; Elveđi Gašparović Vesna ; Barić, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Journal of Inherited Metabolic Disease, JIMD, Volume 39. Suppl.1 (2015) / - , 2015, 95-95

Skup
International Congress of Inborn Errors of Metabolism

Mjesto i datum
Lyon, Francuska, 01.09.2015. - 04.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Pregnant woman with citrullinemia type 1

Sažetak
Background and objective: Citrullinemia type 1 (CTLN 1) is a rare autosomal recessive disorder caused by deficiency of argininosuccinate synthetase. CTLN1 presents as a clinical spectrum ranging from classic neonatal form to late-onset and even asymptomic form. Some women remain undiag-nosed until acute deteriora tion during pregnancy or post partum period. There are no clear recommendations for man- agement of newly diagnosed illness during pregnancy (pregnant women). Case report: A 20-year old women presented at 27th week of gestation with acute liver failure and encephalopathy. As plasma ammonia was high (220 μmol/L) metabolic work-up was performed. Plasma citrulline (921 μmol/L ; N 10-55 μmol/L) and glutamine (1141 μmol/L ; N 340-740 μmol/L) were high, arginine and argininosuccinate were unmeasurably low. Orotic acid excretion in urine was elevated. Treatment with sufficient caloric intake and low protein diet, arginine supplementation and sodium benzoate resulted in complete recovery.Patient tolerated 1.1g protein/kgBW, and probably could more. Plasma ammonia remained normal and amino acids in acceptable range. In 39 th week the patient delivered a healthy baby. Conclusion: Dietary management is an essential part of treatment of pregnant women with citrullinemia type I and contributes to good outcome both for the mother and baby.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

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