Naslov
Prognostic value of routine laboratory tests in patients hospitalized for acutely decompensated chronic heart failure

Autori
Dvornik, Štefica ; Zaninović Jurjević, Teodora ; Paušić, Mihaela ; Vranješević, Mirka ; Jurjević, Nikolina ; Lekić, Andrica ; Zaputović, Luka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clin Chem Lab Med 2016 ; 56(Supplement 1):eA213- eA366 / Agnieszka Pater, Grazyna Sypniewska, Collegium Medicum of Nicolaus Copernicus University - Varšava : European Federation of Clinical Chemistry and Laboratory Medicine (EFLM), European Union of Medical Specialists, Section of Laboratory Medicine/Medical Biopathology, Polish Society of Laboratory Diagnostics, 2016, EA286-eA287

Skup
The 4th Joint EFLM-UEMS Congress “Laboratory Medicine at the Clinical Interface” Warsaw, Poland, 21th–24th September, 2016

Mjesto i datum
Varšava, Poljska, 21.09.2016. - 24.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
heart failure ; clinical laboratory techniques ; prognosis

Sažetak
Aim of the study: Heart failure (HF) is chronic condition that worsens over time. In acute situations it can be life threatening and requires urgent hospitalization. Despite better treatment during last 20 years, prognosis for these patients is still poor. We analyzed laboratory records of emergency hospitalized patients with acute decompensate chronic HF in order to explore their prognostic value regarding the survival of patients. Methods: During four months of examination 165 patients were hospitalized for acute decompensated chronic HF. Laboratory tests were done at the beginning, during and at the end of hospitalization. Laboratory results were analyzed regarding the patients survival. Results: At the end of approximately 9 days of hospitalization 26 of totally 165 patients died (17%). Patients who survive had significantly lower brain natriuretic peptide (NT-proBNP), troponin T (TnT), urea, creatinine and red blood cell distribution width at the beginning of hospitalization than patients who died (P<0.001). NT-proBNP, TnT, urea and creatinine had good discrimination power between survivals and nonsurvivals (P<0.001). NT-proBNP cut-off value was 1254 pmol/L. Patients who survive also had significantly lower uric acid and AST (P<0.005), lower ALP and GGT and better oxygen saturation (P<0.05) at the beginning of hospitalization. At the end of hospitalization patients who survived had lower mean platelet volume (P<0.049) and lower leukocytes (P<0.004) than patients who died. Conclusion: Our study demonstrated that NT-proBNP has the best discrimination power between survivals and non- survivals. Routine laboratory tests are immediately available and can help clinicians in assessment of prognosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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