Naslov
Irritant dermatitis, occupational dermatitis, contact allergy: Differential diagnosis and pitfalls

Autori
Peternel, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25th EADV Congress - Abstracts on USB / - Beč, 2016, 1-1

Skup
25th EADV Congress, Vienna, Austria

Mjesto i datum
Beč, Austrija, 28.09.2016. - 02.10.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
atopic dermatitis ; irritant dermatitis ; contact dermatitis ; patch test ; type IV hypersensitivity

Sažetak
Contact dermatitis most commonly presents as hand eczema, although involvement of face, skin folds or even generalized dermatitis can also occur. Chronic hand eczema as the most frequent clinical presentation of contact dermatitis is often associated with irritant or occupational factors, but it can also arise as a complication of an underlying atopic constitution. In fact, impaired skin barrier in patients with atopic dermatitis (AD) increases the risk of developing irritant contact dermatitis and subsequently of occupational contact dermatitis. Thus, differentiation of all the possible etiological subtypes of contact dermatitis as well as discrimination between allergic contact dermatitis and AD can oftentimes be challenging and require a meticulous workup. Patients with suspected contact dermatitis should be patch-tested to baseline series of allergens, relevant professional allergen series as well as their own samples including work-related, personal-use and cosmetic products. In certain patients prick test and total serum IgE should also be employed. We should be aware of potential pitfalls in the exposure assessment, in the performance of patch test (preparation of allergens, doses, concentrations, reading times) and, finally, in the evaluation of relevance of patch test results. Patients with an impaired skin barrier due to AD or those with wet work- related hand eczema might be predisposed to sensitization by less potent contact allergens which are not included in the standard patch test series. Furthermore, protein contact dermatitis that is common in occupations characterized by significant exposure to plant-or animal- derived proteins will most probably be missed if only patch testing is performed. Ideally, diagnostic workup of a patient with suspected contact dermatitis should provide a precise diagnosis of irritant, allergic contact, atopic or occupational dermatitis. However, these are often found concurrently in a given patient and only an estimation of relative influence of each of the etiological factors can be given.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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