Naslov
Subclinical axonal damage of upper limb’s nerves in OSA patients

Autori
Mihalj, Mario ; Lušić, Linda ; Đogaš, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 23rd Congress of the European Sleep Research Society (ESRS) ; u: Journal of Sleep Research 25 (2016) (S1) 1-401 / - , 2016, 350-351

Skup
Congress of the European Sleep Research Society (23 ; 2016))

Mjesto i datum
Bologna, Italija, 13.09.2016. - 16.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
obstructive sleep apnea ; axonal damage ; nerve

Sažetak
Obstructive sleep apnea (OSA) is a major public health problem with increasing prevalence in parallel with the growing trend of obesity. It is unknown what is the extent of damage to the upper limb’s peripheral nerves in OSA patients. Objectives were to assess the relationship between OSA and amplitudes of evoked action potentials of upper limb’s nerves, and possible impairment of bilateral amplitudes of evoked potentials, both sensory and motor. We conducted an observational cross- sectional study on 43 OSA patients with AHI index >10 confirmed by the whole-night polysomnography (PSG), and 40 controls (without OSA). All subjects underwent standardized electroneurographic testing, with full assessment of amplitudes of evoked compound muscle action potentials (CMAP), sensory neural action potentials (SNAP), nerve conduction velocities, and distal motor and sensory latencies of median and ulnar nerves, bilaterally. All nerve measurements were compared to referent values, as well as between the untreated obstructive sleep apnea patients and control subjects. All subjects were tested with appropriate laboratory tests for known diseases that may affect the peripheral nervous system, and were excluded from the study if history of such diseases and/or tests values and/or clinical findings were positive. The averaged CMAP and SNAP amplitudes were significantly reduced in OSA patients compared with controls, before (P<0.001) and after adjustment for BMI, age and gender. For median nerves (left: P<0, 024 and right: P<0.001) and for ulnar nerves (P=0.002). The subclinical axonal damages of upper limb’s nerves clearly exist in OSA patients. Our results provide another rationale for early start of therapy in order to prevent the development of axonal neuropathy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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