Naslov
Radioprotective effect of a new synthetised adamantyl-thienylcydine

Autori
Ferle-Vidović, Ana ; Jukić, I. ; Škare, D. ; Katušin, J.

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Skup
IRPA Regional Congress on Radiation Protection in Central Europe

Mjesto i datum
Dubrovnik, Hrvatska, 20.05.2001. - 25.05.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
adamantyl derivates

Sažetak
Several adamantyl derivatives of tenocyclidine,1-[1(2-thienylcyclohexyl)]piperidine (TCP), were synthetised and characterised (Ad-TCP I-IV).Their biological activity was evaluated by in vitro testing of their effect on proliferative and reproductive ability of human tumor strain and non- malignant mouse fibroblasts in culture.These effects were compared with those of tenocyclidine (TCP).We also tested them on cultured cells,for their radioprotective effect after ionising irradiation. The results with non-malignant mouse fibroblasts and human tumour cells show that the piperidine derivative of adamantyl tenocyclidine (Ad-TCP II)has rather outstanding radioprotective properties.This derivative revealed significant radioprotection at all survival levels,depending on the malignant or non-malignant origin of the cells,and it was significantly more evident on mouse fibroblasts then on human tumor cells.These effects were compared with those of tenocyclidine. Introduction Materials and methods

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA