Naslov
IDIOSYNCRATIC REACTIONS: LABORATORY ANSWERS TO CLINICAL QUESTIONS

Autori
Bojić, Mirza ; Antolić, Andrea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
8th Croatian Congress of Pharmacology with International Participation - Final Programme and Book of Abstracts / Boban, Mladen - Split : Hrvatsko farmaceutsko društvo, 2016, 31-31

Skup
8th Croatian Congress of Pharmacology with International Participation

Mjesto i datum
Split, Hrvatska, 15.09.2016. - 18.09.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
IDR; reactive metabolites; drug metabolism

Sažetak
Idiosyncratic drug reactions (IDR) are rare, dose independent adverse drug reactions. Although non-predictable they are not idiopathic and their causes can be rationalized. As IDRs appear rarely (with a frequency of less than 0.1%) they are encountered when a drug comes to the market and is exposed to larger population. Drugs susceptible to IDRs usually undergo extensive metabolism, consequently most common IDR is hepatotoxicity caused by reactive metabolites. In this presentation laboratory approaches in search of reactive metabolites will be discussed. Some of the topics covered: why did structurally similar pioglitazone and rosiglitazone outsurvive troglitazone, why is paracetamol still the leading cause of acute liver failure, is glucuronidation detoxication reaction, can parent drugs be responsible for enzyme inactivation?

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA