Naslov
COGNITIVE DYSFUNCTIONS IN ASEPTIC MENINGITIS CAUSED BY THE ECHO VIRUS – CASE REPORT

Autori
Petković, Dobrinka ; Vuković, Borislav ; Galić, Slavka ; Andrić, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract book / - , 2015, 81-81

Skup
55th International Neuropsichiatric Congress

Mjesto i datum
Pula, Hrvatska, 27.05.2015. - 30.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ECHO virus

Sažetak
Enteroviruses included in family Picornavirideae are separated into subgroup and serotypes: Polioviruses, Coxsackie viruses A and B serotypes, Echoviruses serotypes 1-24, Enteroviruses serotypes 68-75. Enteroviruses including poliovirus account for only 11-22% of all cases of encephalitis. Clinical spectrum of infection with ECHO viruses is extensive: asymptomatic infection, febrile illness with or without respiratory symptoms and CNS infections – aseptic meningitis, encephalitis, paralysis, Guillain–Barre syndrome. Objectives: Review of follow-ups during a one-year period of a female patient with aseptic meningitis, cognitive dysfunction and an electroencephalographic record showing abnormalities. Previous psychiatric and neurological diseases were anamnestically excluded, in early childhood patient get over aseptic meningitis without aftermath .Physical and neurological examinations suggested the clinical diagnosis of aseptic meningitis characterized by fever, headache, meningismus with no focal neurological signs. The diagnosis was confirmed by CSF examination which revealed lymphocytic pleocytosis and negative bacteriological cultures. Etiologic diagnosis was confirmed by serological examination (ELISA) of paired serum samples (acute and convalescent phase disease) for enteroviruses performed at the Croatian National Institute of Public Health, Zagreb. EEG recordings were evaluated according to standards for the patient’s age on a 21 channel Medelec apparatus. Cognitive functions assessed using psychological tests (Interview, WBII, AVLT, WMS, CFT, Bender Gestalt II, FAS, MMPI-2) CSF contained 491 white cells/mm3 (90.2% lymphocytes), Glucosae level 2.8 mmol/L , Protein content 0, 65g/L. Results of serologic examination in the acute disease phase showed positive specific IgM antibodies on Echoviruses, indicating recent infection. ECHO IgM 48 , IgG 180 U/ml, Poliovirus IgG positive 1.18, Coxsackiae v. IgM negative <10, IgG positive 300 Convalescence phase: Echoviruses IgM 15 negative, IgG 140. EEG record in acute phase: diffused dysrhythmically changed predominantly in frontal region with paroxysmal tendency during hyperventilation. Control EEG record one year later: lighter irregularity in frontal region with paroxysmal tendency during hyperventilation. MRI brain scan was normal. Result of psychological testing: Average general intellectual functioning, memory disorders – mildly reduced verbal long term memory, verbal – logical long term and visual memory. Moderately reduced verbal fluency. This cognitive dysfunction indicates organic cerebral dysfunction. After a one-year period, follow-up on a 30-year old female patient with aseptic meningitis caused by Echovirus and organic cerebral dysfunction development manifested by a symptomatology of memory disorders and diffuse abnormalities in electroencephalographic record showed spontaneous cognitive functions normalization, but EEG records still show localised irregularities in the frontal regions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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