Naslov
THE BURDEN OF ACUTE ROTAVIRUS GASTROENTERITIS IN CROATIAN CHILDREN – A MULTICENTER PROSPECTIVE STUDY ON CLINICAL CHARACTERISTICS AND MOLECULAR EPIDEMIOLOGY (2012 – 2014).

Autori
• Vrdoljak M, Papić N, Gužvinec M, Butić I, Payer-Pal M, Hegeduš-Jungvirth, Marija ; Tonkić, Marija ; Krželj, Vjekoslav ; Ivić, Ivo ; Tešović, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
34th Annual Meeting of the ESPID / - Brighton, 2016, 835-836

Skup
34th Annual Meeting of the ESPID

Mjesto i datum
Brighton, Ujedinjeno Kraljevstvo, 10.05.2016. - 14.05.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Rotavirus; Genotype; Croatia

Sažetak
Background Rotavirus (RV) infection is the major cause of infectious diarrhoea in children under age 5. The aim of the study was to determine the epidemiology, seasonality, disease severity and genotype distribution of RV strains causing young children's acute gastroenteritis (AGE) in Croatia. RV vaccine is not a part of NIP in Croatia. Methods 1571 children with all-cause AGE, aged less than 5 years, were included in this prospective multicentric study from July 2012 to July 2014. Vesikari and Clark severity scores were calculated, routine laboratory tests were performed and one stool sample was taken for microbiological testing. RV positive samples were further molecularly analysed. Results A total of 735 (46.8%) samples were RV positive. RV was the most common cause of AGE in all age groups.The majority of RV AGE were recorded in January and February 2014 (93 and 90, respectively). RV-positive patients were younger than RV-negative ones (p = 0.0168). No sigificant differences in laboratory findings were found between two groups of patients. Comparing Vesicari score, more RV-positive patients had moderate to severe illness than RVnegative (p = 0.0015). Using Clark score, no differences were found between groups. G1P8 was the most common RV genotype (60.5%), followed by G2P4 (21.2%), G1P4 (3.3%), G3P8 (3.3%), G2P8 (3%), G9P8 (2.5%). There were significant differences in geographic distribution of RV genotypes (Table 1). Genotype G2P8 was associated with higher Clark and Vesikari scores compared with other genotypes.No significant differences in genotype distribution by age groups and by different seasons were found. Conclusions RV is the most common cause of AGE in Croatian children aged < 5 years. RV genotypes show differences in geographic distribution, as well as in clinical severity of disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA