Pregled bibliografske jedinice broj: 831782
The Evolution of Viruses in Multi-Host Fitness Landscapes
The Evolution of Viruses in Multi-Host Fitness Landscapes // The Open virology journal, 3 (2009), 1-6 doi:10.2174/1874357900903010001 (podatak o recenziji nije dostupan, pregledni rad, znanstveni)
CROSBI ID: 831782 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The Evolution of Viruses in Multi-Host Fitness Landscapes
Autori
Elena, Santiago F. ; Agudelo-Romero, Patricia ; Lalić, Jasna
Izvornik
The Open virology journal (1874-3579) 3
(2009);
1-6
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
specialism-generalism; virus adaptation; antagonistic pleiotropy; virus fitness
Sažetak
Provided that generalist viruses will have access to potentially unlimited hosts, the question is why most viruses specialize in few hosts. It has been suggested that selection should favor specialists because there are tradeoffs limiting the fitness of generalists in any of the alternative hosts or because evolution proceeds faster with narrower niches. Here we review experiments showing that virus adaptation to a specific host is often coupled with fitness losses in alternative ones. In most instances, mutations beneficial in one host are detrimental in another. This antagonistic pleiotropy should limit the range of adaptation and promote the evolution of specialization. However, when hosts fluctuate in time or space, selective pressures are different and generalist viruses may evolve as well.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
