Naslov
Iron induces proliferation and morphogenesis in primmorphs from the marine sponge Suberites domuncula

Autori
Krasko, Anatolij ; Schroder, Heinz C. ; Batel, Renato ; Grebenjuk, Vladislav A. ; Steffen, Renate ; Muller, Isabel M. ; Muller, Werner EG

Izvornik
DNA and Cell Biology (1044-5498) 21 (2002), 1; 67-80

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
marine sponges; Suberites domuncula; primmorphs; proliferation and morphogenesis; septin; silicatein; iron

Sažetak
Dissociated cells from marine demosponges retain their proliferation capacity if they are allowed to form special aggregates, the primmorphs. On the basis of incorporation studies and septin gene expression, we show that Fe3+ ions are required for the proliferation of cells in primmorphs from Suberites domuncula. In parallel, Fe3+ induced the expression of ferritin and strongly stimulated the synthesis of spicules. This result is supported by the finding that the enzymatic activity of silicatein, converting organosilicon to silicic acid, depends on Fe3+. Moreover, the expression of a scavenger receptor molecule, possibly involved in the morphology of spicules, depends on the presence of Fe3+. We conclude that iron is an essential factor in proliferative and morphogenetic processes in primmorphs.

Izvorni jezik
Engleski

Znanstvena područja
Geologija

POVEZANOST RADA