Pregled bibliografske jedinice broj: 830420
Exploring Fluorescent Benzimidazo[1, 2- a]quinolines for Candida spp. Bio lm Detection and Biocidal Activity
Exploring Fluorescent Benzimidazo[1, 2- a]quinolines for Candida spp. Bio lm Detection and Biocidal Activity // 27th European Colloquium on HETEROCYCLIC CHEMISTRY, Amsterdam / Orru, R. V. A. ; Ruijter, E (ur.).
Amsterdam, 2016. str. 153-153 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 830420 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Exploring Fluorescent Benzimidazo[1, 2- a]quinolines for Candida spp. Bio lm Detection and Biocidal Activity
Autori
De Souza, Igor O. P. ; Schrekker, Clarissa M. L. ; Lopes, William ; Orru, Romano V. A. ; Hranjec, Marijana ; Perin, Nataša ; Machado, Michel ; Oliveira, Luís F ; Stefani, Valter ; Schrekker, Henri S. ; Fuentefria, Alexandre M.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
27th European Colloquium on HETEROCYCLIC CHEMISTRY, Amsterdam
/ Orru, R. V. A. ; Ruijter, E - Amsterdam, 2016, 153-153
Skup
27th European Colloquium on HETEROCYCLIC CHEMISTRY
Mjesto i datum
Amsterdam, Nizozemska, 03.07.2016. - 06.07.2016
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Yeast; biological probes; stainless steel; leukocyte cytotoxicity; fungal biomarkers.
Sažetak
Resistance mechanisms like biofilms provide a protection for microbial cells from damage caused by humoral and cellular immune system components, promoting infections and increasing mortality and morbidity of patients1, 2. This study evaluated nine fluorescent benzimidazo[1, 2-α]quinolines3 NBx as bifunctional agents that both detect and eradicate fungal biofilms on stainless steel surfaces, in order to provide an innovative solution for preventing contamination in hospital environments. The benzimidazoles’ staining capability was determined by a microscopy study and spraying tests on fungal biofilm contaminated stainless steel surfaces. Furthermore, their cytotoxicity was evaluated with trypan blue and their biocidal activity was determined as the minimum inhibitory concentration against Candida tropicalis, C. albicans and C. parapsilosis. This resulted in the identification of NB7, which presents all the desired characteristics and capabilities (staining and biocide activity against all tested biofilm forming fungal strains) at the same time. As such, benzimidazole NB7 has the potential to guarantee the use of disinfected medical and surgical instruments in clinical and surgical procedures, consequently, contributing to an increased safety for patients.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija
POVEZANOST RADA
Projekti:
HRZZ-IP-2013-11-5596 - Sinteza i citostatska ispitivanja biblioteke novih dušikovih heterocikla (SCIENcENTRY) (Raić-Malić, Silvana, HRZZ - 2013-11) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
